The Development of diazepam as an anxiolytic Essay

The Development of diazepam as an anxiolytic - Essay Example Later, diazepam was marketed in 1963 by Hoffmann–La Roche under the trade name Valium. Thus two drugs emerged as the most successful commercially available drugs revolutionizing the science of anti-anxiolytic drugs. By the year 1970s they potentially replaced older drugs for sedative and hypnotic uses (Shorter, 2005). Diazepam belongs to benzodiazepine group. Diazepam acts on ascending reticular formation (responsible for wakefulness) in midbrain and on limbic system (responsible for thought). Muscle relaxation is produced by primary medullary site of action and ataxia is due to action on cerebellum (Tripathi, 2008; Rang & Dale, 2007; Brunton, 2005). Diazepam binds to benzodiazepine binding site on GABAA receptor Cl- channel complex. GABAA receptor is a pentameric structure (like a lily flower). It contains many sub-units and encloses Cl- channel. The opening of Cl- channel is modulated by GABA. Diazepam by binding to benzodiazepine binding site (ÃŽ ±/ÃŽ ³ subunit interface) facilitates GABA action (more amount of GABA will bind to GABAA receptor). It is not a GABA mimetic, it only facilitates GABA mediated Cl- channel opening. Opening of Cl- channel causes influx of Cl- ions and causes hyperpolarization. This decreases the firing rate of neurons. Therefore it possesses hypnotic action- induction of sleep- reticular activating system- depresses CNS- decreases the spread of epileptic discharge, therefore possesses anticonvulsant action (Tripathi, 2008; Rang & Dale, 2007; Brunton, 2005). The chloride channel is gated by the primary ligand GABA acting on GABAA receptor located on the ÃŽ ²- subunit. The benzodiazepine (BZD) receptor located on the interface of ÃŽ ± and ÃŽ ³ subunits modulates GABAA receptor in either direction (Tripathi, 2008). Oral absorption of Diazepam is good. Diazepam is widely distributed in body; absorption from intramuscular site of administration is

Service Product Marketing Essay Example | Topics and Well Written Essays - 2750 words

Service Product Marketing - Essay Example Greece does receive both tourists and business travellers who face such inconveniences. A Spa at the airport would be able to capture this segment through the right marketing approach. This would be a mass marketing approach through the right mix of the seven element of service marketing. It is strongly recommended that the tourism venture should be an airport spa in Greece and the promotion of this spa can be done through innovative strategies such as tie upasana with the airlines and tour operators. Local people can also be attracted to the day spa which would tale care of business during the lean tourist season. Tourism in the 20th century has grown as the world’s largest industry surpassing autos, steel, electronics, and agriculture (Sirgy & Su, 2000). It is undoubtedly a large source of foreign exchange, employment and income and has grown as the business of attracting visitors and catering to their needs The economy of a nation depends on the travel and tourism industry and this is further endorsed by the fact that post September 11, the industry lost $1.36 billion in business because of a dramatic drop in bookings for flights, hotel rooms, car rentals and cruise. However, tourism is a service sector and the success of any tourism product depends on the service delivery. The process of globalization and social changes has transformed the service economy (Lovelock, Wirtz & Chew, 2009). Innovation in the service products stimulated by technology allows the service provider to offer a wider choice to the consumers. In addition, the disposable income in the hands of the people has gone up while their lifestyles have changed as well. This report aims to explore the strategy for marketing day spas in Greece. Greece continues to have the image of the 1960s as ‘island-hopping backpackers and package tourists’ (Mjourney, 1998). To attract the upmarket clients it is very important for Greece

Advantages and Disadvantages of Social Networking Essay Example for Free

Advantages and Disadvantages of Social Networking Essay Social networking sites have become extremely popular among the youth as well as the professional people. Keeping in mind, the growing popularity of these sites and the effect it has and the benefits that it brings along, it can be easily predicted that its popularity is sure to grow much more. The social networking websites are more like the virtual meeting places where people can just chill and hang out with friends. They can discuss on different topics, share information, and exchange files and pictures. We admitted the fact that using social networking is one way to enhance our social interaction with other people. Because of our technologies there are many ways that can help our works faster and easier. However, everything has a positive and negative side. Similarly, the social networking sites are also made up of their set of advantages and disadvantages; it is a one way to communicate our distant relatives or families, it’s a big help for the people who needs jobs especially there are online jobs offered in social networking and also it’s a way for some students who wants to finish their study due to their personal problems because there are many distance learning here in social networking. But among those advantages we can get from social networking, there are still many disadvantages that can affect to the users. Students are the one who are really affected for the disadvantages of social networking. According to the some surveyors many students are addicted to some social networking. That can lead them not to go to their classes’ hours. There are some social networking’s that are prohibited for minor children. Because of that, the cases now for the minor children like harassment, rape and etc. are getting higher. Because some are getting influence by what they have saw or learned from that social networking. In using social networking, it must be minimal and the users should know how it affects to her /his life so that there will be no regrets at the end. Do whatever you want as long as it can lead you on a better way and a peaceful life.

Overview of Famous Mathematicians

Overview of Famous Mathematicians Mathematicians’ Manifesto A young man who died at the age of 32 in a foreign land he had travelled to, to pursue his craft. A clumsy eccentric who could visualize his complete work in his head before he put it to canvas. A Russian who shuns the limelight and refuses recognition for his work. A traveller who went from country to country on a whim in order to collaborate with others. A man whose scribblings inspired the life work of hundreds. A woman, who escaped the prejudices against her gender to make a name for herself. A recluse who spent close to ten years working on one piece. A revolutionary child prodigy who died in a gun duel before his twenty-first birthday. What do you picture when you read the above? Artists? Musicians? Writers? Surely not mathematicians? Srinivas Ramanujan (1887-1920) was a self-taught nobody who, in his short life-span, discovered nearly 3900 results, many of which were completely unexpected, and influenced and made entire careers for future mathematicians. In fact there is an entire journal devoted to areas of study inspired by Ramanujan’s work. Even trying to give an overview of his life’s work would require an entire book. Henri Poincare (1854-1912) was short-sighted and hence had to learn how to visualise all the lectures he sat through. In doing so, he developed the skill to visualise entire proofs before writing them down. Poincare is considered one of the founders of the field of Topology, a field concerned with what remains when objects are transformed. An oft-told joke about Topologists is that they can’t tell their donut from their coffee cup. A conjecture of Poincare’s, regarding the equivalent of a sphere in 4-dimensional space, was unsolved till this century when Grigori Perelman (1966- ) became the first mathematician to crack a millenium prize problem, with prize money of $1million. Perelman turned it down. He is also the only mathematician to have turned down the Fields Medal, mathematics’ equivalent of the Nobel Prize. Have you heard of the Kevin Bacon number? Well mathematicians give themselves an Erdos number after Paul Erdos (1913-96) who, like Kevin Bacon, collaborated with everybody important in the field in various parts of the world. If he heard you were doing some interesting research, he would pack his bags and turn up at your doorstep. Pierre de Fermat (1601-65) was a lawyer and ‘amateur’ mathematician, whose work in Number Theory has provided some of the greatest tools mathematicians have today, and are integral to very modern areas such as cryptography. He made an enigmatic comment in a margin of his copy of Diaphantus’ ‘Arithmetica’ saying: ‘It is impossible to separate a cube into two cubes, or a fourth power into two fourth powers, or in general, any power higher than the second, into two like powers. I have discovered a truly marvellous proof of this, which this margin is too narrow to contain.’ Whether he actually had a proof is debatable, but this one comment inspired work for the next 300 years. In these intervening 300 years, one name has to be mentioned Sophie Germain (1776-1831). Germain remains one of the few women who have broken the glass ceiling and made significant contributions to mathematics. She was responsible for proving Fermat’s scribblings for a large amount of numbers. I apologise to Andrew Wiles (1953- ) for calling him a recluse, but he did spend close to 10 years on the proof of Fermat’s Last Theorem, during most of which he did not reveal his progress to anybody. Saving the best for last, Evariste Galois (1811-32), a radical republican in pre-revolutionary France, died in a duel over a woman at the age of 20. Only the night before, he had finished a manuscript with some of the most innovative and impactful results in mathematics. There is speculation that the resulting lack of sleep caused him to lose the duel. Galois developed what became a whole branch of mathematics to itself Galois Theory, a sub-discipline which connect two other subdisciplines of abstract algebra. It is the only branch of mathematics I can think of which is named after its creator (apart from Mr. Algebra and Ms. Probability). This might appear to be anecdotal evidence of the creative spirit of mathematics and mathematicians. However, the same can be said about the evidence given for Artistic genius. In fact there is research which shows that the archetype of a mad artistic genius doesn’t stand on firm ground. So, lets move away from exploring creative mathematicians, to the creativity of the discipline. Mathematics is a highly creative discipline, by any useful sense of the word ‘creative.’ The study of mathematics involves speculation, risk in the sense of the willingness to follow one’s chain of thought to wherever it leads, innovative arguments, exhilaration at achieving a result and many a time beauty in the result. Unlike scientists, mathematicians do not have our universe as a crutch. Elementary mathematics might be able to get inspiration from the universe, but quickly things change. Mathematicians have to invent conjectures from their imagination. Therefore, these conjectures are very tenuous. Most of them will fail to bear any fruit, but if mathematicians are unwilling to take that risk, they will lose any hope of discovery. Once mathematicians are convinced of the certainty of an argument, they have to present a rigorous proof, which nobody can poke any holes in. Once again, they are not as luck as scientists, who are happy with a statistically signific ant result or at most a result within five standard deviations. As a result of this, once you prove a mathematical theorem, your name will be associated with it for eternity. Aristotle might have been superseded by Newton and Newton by Einstein, but Euclid’s proof of infinite primes will always be true. As Hardy said, â€Å"A mathematician, like a painter or poet, is a maker of patterns. If his patterns are more permanent than theirs, it is because they are made with ideas.† The beauty of mathematical results and proofs is a fraught terrain, but there are certain results, great masters such as Euler’s identity and Euclid’s proof, which are almost universally accepted as aesthetically pleasing. So, why are people so afraid of mathematics? Why do they consider it to be boring and staid? Well, the easy answer is that they are taught shopkeeper mathematics. In school, you are taught to follow rules in order to arrive at an answer. In the better schools, you are encouraged to do so using blocks and toys. However, basically the only skills you are getting are those which help you in commercial transactions. At the most, you get the skills to help you in other disciplines like Economics and the Sciences. There has been a huge push in the recent past for the Arts to be taught in school ‘for art’s sake.’ There would be uproar tomorrow amongst artists and the liberal elite if art class turned into replicating posters (not even creating them). There would even be a furore if the only art students did was to draw the solar system for Science class and the Taj Mahal for Social Studies. What good art classes involve is teachers introducing concepts such as particular shapes and then encouraging students to experiment and create based on those concepts. What about ‘maths for maths’ sake?’ Students should be encouraged to come up with their own conjectures based on concepts introduced by the teacher. This class would have to be closely guided by a teacher who is conceptually very strong, so that they can give examples in order to get students to come up with conjectures. They would also be required to provide students with counterexamples to any conjecture they have come up with. I am not suggesting completely doing away with the current model of mathematics education involving repeated practice of questions. Just as replication probably helps in the arts and the arts can serve as great starting points for concepts in other disciplines, repetition is important in mathematics as it helps you intuit concepts and certain mathematical concepts are important for the conceptual understanding of other disciplines and for life. So, there needs to be a blend of mathematics classes (those which teach mathematics) and shopkeeper classes (those which teach mathematical concepts for other disciplines and for life). These would not work as separate entities and might even be taught at the same time. This requires a complete overhaul of the mathematics curriculum with a much lighter load of topics so that teachers can explore concepts in depth with their students. It also requires a larger emphasis on concepts such as symmetry, graph theory and pixel geometry which are easi er to inquire into and form conjectures in than topics like calculus. Now we come to the logistics. How many teachers are there in the country who have a strong enough conceptual understanding required to engage with mathematics in this manner? I would be pleasantly surprised if that were a long list, but I suspect it isn’t. In order to build up this capability, the emphasis at teacher colleges and in teacher professional development has to move from dull and pointless concepts like classroom management and teaching strategies, to developing conceptual understanding, at least in Mathematics. The amount of knowledge required to teach school mathematics is not all that much. All that is required is a strong conceptual base in a few concepts along with an understanding of mathematics as an endeavor, and a disposition for the eccentricities of the discipline. Even so, this will not be easy to accomplish and will take time. In the meanwhile, wherever possible, professional mathematicians could come in to schools and work with teachers on their lesson plans. In other cases, these mathematicians could partner with educationalists and come up with material, which can more or less be put to use in any class (this is not ideal as lesson plans should be created by the teachers and evolved based on their understanding of their class, but this will have to do in the interim). Not only will this help in developing a disposition for mathematics and hopefully churn out mathematicians, but it will also help in the understanding of shopkeeper mathematics. Pedagogy and conceptual understanding are not separate entities. In fact a strong conceptual understanding is a prerequisite for effective pedagogy. Mathematics is unfortunate in its usefulness to other disciplines and the utility it provides for life. In the meanwhile, the real creative essence of the discipline is lost. I don’t blame students for hating mathematics in school. In fact it is completely justified. Mathematics is missing out. Who knows, one of these students would have proved the Riemann Hypothesis in an alternate reality. Artists have been very successful in campaigning for the creativity of their discipline to be an integral part of schools. Mathematicians, on the other hand, really need to pull up their socks and join the fight for the future of mathematics. In the spirit of Galois, Mathematicians of the World Unite! You have nothing to lose but the chains of countless students!

Feminist and Dialogic Approaches in The Fatal Sisters :: The Fatal Sisters

Feminist and Dialogic Approaches in The Fatal Sisters  Ã‚     Ã‚   Thomas Gray's method of transforming monological poems into intense psyche films is fascinating. While reading The Fatal Sisters, readers can actually engage in a mind performance because of the choices of words, vivid actions, social aspects, and mythology that Gray displays here. The feminist and dialogic approaches, applied together, help shape the realm of this poem into a complex event in history that still takes place today. The feminist approach reveals many things about this poem that would otherwise be overlooked. To start, Gray presents us with Norse mythology. The twelve women in this poem are acknowledging the maidens of Oden who conduct the souls of heroes slain in the battle of Vahalla. This poem is their song. It sounds as a prayer that they are reciting to the war maidens Mista, Sangrida, and Hilda. "It is well-documented that in many cultures, when matriarchal societies were replaced with patriarchal ones, the previously venerated goddesses were turned by the new culture into witches, seductresses, or fools."(Guerin 207) These women's matriarch society was turned into a patriarch society. This is why the battle is going on. Supreme classes of men are combating for more power. The power that men took away from old matriarchal archetypes. Another approach helpful in analyzing this poem is Marxist feminism. Marxist feminism points out the social class that these women are in and leads us further to determine their fate. The women in The Fatal Sisters belong to the working class. They constitute a union and are bonded by sisterhood. The writers of the 1970's movie, Norma Rae, had this poem in mind when making this film. The Fatal sisters know their job. The fate of the men's lives are in the sisters hands. "Glitt'ring lances are the loom, where the dusky warp we strain, weaving many a soldier's doom, Orkney's woe, and Randver's bane."(5-8) The sisters are not affected by the war that is taking place. Their only focus is their duties, which are to finish making war flags and aid in killing. The biological and liguistical models also shape the feminine approach. The preface draws a detailed abstract to what these women look like. "Till looking through an opening in the rocks he saw twelve gigantic figures resembling women."(Gray 38) This is very offensive. He could have called them sturdy women, or large women.

The Urban Legend of Tommy Hilfiger :: essays research papers fc

The Truth about the Rumor of Tommy Hilfiger A big controversy happened, the well-known Fashion Designer Tommy Hilfiger was on the Oprah show. She asked him if it was true if he said he did not make clothes for Blacks and Asians, his clothes were intended for upper class White people. When he admitted he said those things, she asked him to leave. This E-Mail is an Urban Legend. Juicy Emails like these are simply for entertainment purposes only and should not be taken seriously. Like junk mail it should be emptied into the recycle bin. People assume if an E-mail is sent to them or if a friend mentioned the incident then it must be true. How could someone write something so mean and cruel and spread it through emails? Thomas Craughwell explains that â€Å"fear, paranoia, envy and suspicion of unfamiliar† are reasons why urban legends such as Tommy Hilfiger are passed around (Craughwell 10). People read newspapers such as the Inquirer and read junk E-mails at work to make the day go by. Richard Roeper describes people as â€Å"today’s information consumer†, who are â€Å"savvy, jaded and cynical† (Roeper 10). It’s no secret that people can be gullible when it comes to interesting news. Roper states that people are as â€Å"willing as ever to believe stories that happened to best friend’s brother’s accountant† (Roper 11). People have gotten too lazy to look up information for themselves and look for quick fixes, instead of facts. The Tommy Hilfiger Rumor has all of the signs of the urban legend. As Defined by Craughwell â€Å"urban legends are usually passed by word of mouth and by E-mail†. Urban legends have many variations (Craughwell 9,13). David Emery from About.com has two of the most common variations of the E-mail in his article. Before there were any rumors of him on the Oprah Show, It was a â€Å"news article† in a â€Å"Philippian tabloid in 1996† as Barbara Mikkelson explains in her article. According to Barbara Mikkelson, the rumor was altered again with him being on the CNN style show with Elsa Klensch . In this rumor he did not comment on black people. He commented about â€Å"Asian people not looking right in the clothes† (Barbara Mikkelson). Although the rumors are being shown to be not true, they are still being passed around to this day (David Emery). People who are in the know about rumors made inquiries to the Anti Defamation League.

Citizens Have to a Guaranteed Minimum Income in a Democratic Society Essay

â€Å"Although abuse of the system are inevitable, social welfare payments are essential to protect the rights citizens have to a guaranteed minimum income in a democratic society† Discuss. Social welfare is an essential element of an advanced society. Good systems are always abused, but that does not mean they are faulty. In my opinion, the two main reasons why welfare payments are necessary are as follows: First of all, critics forget that there are many forms of welfare besides payments to the unemployed. Their negative opinions harm those who are not capable of earning a wage, such as single-parent mothers, the disabled, and the sick. Moreover, the unemployed have the right to an income, too. They are not always at fault for not having a job, and in most cases the tax they have paid in the past entitles them to assistance. The second reason is that crime increases when people have no means of support. The desperately poor inevitably turn to crime, which is not only dangerous but costly. Policing the streets is more expensive than providing welfare. A policeman’s wage is four or five times higher than a â€Å"dole† payment. Certain members of society believe that people should look after themselves. They point out that welfare increases dependency on others and destroys dignity. This may be true, but in the case of the unemployed, the relief payments are usually temporary. It is surely the fault of the government if there are long-term unemployed. Welfare critics also believe that it is the responsibility of a victim’s family to provide financial assistance. However, it is too expensive to provide complete help for a severely disabled person. To conclude, it is vital to understand the need for welfare in a modern democratic society. Without welfare payments the poor are destined to become poorer. The first duty of a government is to provide a financial safety net for all disadvantaged persons, and that includes those without work.